Roberto Di Maio

This study identifies 15-lipoxygenase-mediated lipid peroxidation as a regulator of LRRK2 kinase activity, linking it to Parkinson's disease pathogenesis.

The paper demonstrates that neuronal NOX2 contributes to oxidative stress, α-synuclein pathology, and LRRK2 activation in Parkinson's disease and shows that NOX2 inhibitors can prevent these effects in a rat model.

This study shows that disulfide bridge formation in CaMKII disrupts its interaction with calmodulin in Parkinson's disease, linking oxidative stress to impaired Ca2+/CaM signaling.