Neuronal NADPH oxidase in Parkinson disease pathogenesis
Matthew T. Keeney, Eric K. Hoffman, Kyle Farmer, Christopher R. Bodle, Marco Fazzari, Alevtina Zharikov, Sandra L. Castro, Julia K. Kofler, Eugenia Cifuentes-Pagano, Patrick J. Pagano, Edward A. Burton, Teresa G. Hastings, J. Timothy Greenamyre, Roberto Di Maio
The paper demonstrates that neuronal NOX2 contributes to oxidative stress, α-synuclein pathology, and LRRK2 activation in Parkinson's disease and shows that NOX2 inhibitors can prevent these effects in a rat model.
bioRxiv · May 13, 2021 · PreprintNeuroscience