Edward A. Burton

The paper develops a method to ablate specific synaptic connections in neurons using optogenetic tools, demonstrating its application in zebrafish to disrupt functional connectivity and observe behavioral effects.

This paper investigates the association between chlorpyrifos exposure and Parkinson's disease risk, finding increased odds of PD with long-term exposure and demonstrating causal mechanisms in animal models.

The paper shows that tau load in specific brainstem neurons predicts balance deficits before cell death in zebrafish.

This paper develops a larval zebrafish model of TBI to optimize injury severity for studying treatment and aetiology, observing correlations between injury levels and clinical phenotypes like seizures and tau aggregation.

The paper demonstrates that neuronal NOX2 contributes to oxidative stress, α-synuclein pathology, and LRRK2 activation in Parkinson's disease and shows that NOX2 inhibitors can prevent these effects in a rat model.

This study shows that post-traumatic seizures and dynamin-dependent endocytosis promote tauopathy spread after TBI using a zebrafish model.

This study demonstrates that zebrafish can regenerate a functional RPE monolayer after widespread RPE ablation, with regeneration originating from peripheral RPE cells and requiring Wnt signaling.