CD8 T cells mediate immunosurveillance for neoantigen+ epithelial stem cells in the colon
Jessica N. Buck, Nivedita R. Iyer, Eric Fagerberg, Goran Micevic, Jiaming He, Kerri St. Denis, Vyom Shah, Holly N. Blackburn, Srividhya Venkatesan, John Attanasio, Brian G. Hunt, Alex Dalrymple, Liza Konnikova, Semir Beyaz, Martina Damo, , Nikhil S. Joshi
This study shows CD8 T cells eliminate neoantigen+ epithelial stem cells in the colon, preventing cancer, without causing immunopathology.
bioRxiv · Oct 19, 2025 · PreprintImmunology