Liza Konnikova

The paper presents the Human Gut Cell Atlas v1.0, a unified reference of gut cell diversity, revealing how tissue structure influences cellular composition and enabling disease and organoid analysis.

Anakinra reduced preterm labor and inflammation in a Rhesus macaque model of E. coli-induced intrauterine infection.

This study shows that early-life mucosal T cells promote intestinal stem cell renewal and secretory differentiation through direct interactions and signaling, with impaired function in NEC and adult T cells.

The paper identifies serotonin and related gene expression patterns in human intestinal development using single-cell transcriptomics, revealing cell-type-specific roles in gut development.

This study shows CD8 T cells eliminate neoantigen+ epithelial stem cells in the colon, preventing cancer, without causing immunopathology.

The paper examines immune cell composition and function in placental villi, finding that excessive T cells and cytokines in preterm cases impair trophoblast health.

The paper identifies BACH2-driven tissue-resident memory programs in gut CD4+ T cells as a mechanism promoting HIV-1 persistence and suggests BACH2 as a therapeutic target.

This study investigates the combination of DNA methyltransferase inhibitor decitabine and PD-1 inhibitor in high-risk pediatric brain tumor models, finding improved survival in some subtypes.

The paper shows that microbial metabolites in fetal intestines are maternally derived and may regulate fetal immunity and prepare the gut for postnatal microbes.

This study evaluates manual gating, unsupervised clustering, and auto-gating methods for high-dimensional cytometry data using six datasets and provides practical guidelines for selecting appropriate methods.

The paper uses bulk RNA-Seq to analyze gene expression changes in mouse duodenum and ileum during the first postnatal month, identifying key molecular shifts and comparing them to human data.

The paper identifies a subset of fetal enteroendocrine cells expressing insulin and beta cell genes, suggesting an extra-pancreatic source of beta cells.

CITE-sort improves cell type classification in CITE-seq by addressing artificial cell types caused by multiplets, achieving better clustering performance than existing methods.