Eric Fagerberg

This paper describes a standardized method to replace T cell receptors in murine CD8 T cells using CRISPR-Cas9 and retroviral transduction, enabling efficient genetic manipulation for in vitro and in vivo studies.

The paper shows that humanized Traf6 promoter sequences in mice affect immune responses but not fertility, revealing distinct roles for germ and immune cells in gene regulatory evolution.

This study identifies Regnase-1 and SOCS1 dual-inactivation as a strategy to enhance anti-tumor functionality of CD8+ T cells by rewiring their differentiation and effector state.

This study shows CD8 T cells eliminate neoantigen+ epithelial stem cells in the colon, preventing cancer, without causing immunopathology.

This paper introduces GSPA, a method to map gene space at single-cell resolution, enabling gene characterization and analysis of gene expression patterns across biological tasks.