Sphingolipid Homeostasis, Mitochondrial Activity, and PKA Signaling Drive an Azole-Tolerant State
Cécile Gautier, Eli Isael Maciel, Corinne Maufrais, Naomi Lyons, Nora Kawar, Chen Bibi, Caleb Eickmann, Alex Rosenberg, Deveney Dasilva, N De, Maurizio Del Poeta, Richard J. Bennett, Judith G. Berman, Iuliana V. Ene
This study identifies Mnl1 as a repressor of azole tolerance in Candida albicans by linking it to sphingolipid metabolism, mitochondrial activity, and PKA signaling.
bioRxiv · Sep 12, 2025 · PreprintMicrobiology