The paper develops and validates a 16-plex droplet digital PCR assay for accurate chromosome copy number quantification in C. albicans, showing strong correlation with whole-genome sequencing.

G3 Genes Genomes Genetics · Jul 28, 2026Peer-reviewedMicrobiology

Sphingolipid Homeostasis, Mitochondrial Activity, and PKA Signaling Drive an Azole-Tolerant State

Cécile Gautier, Eli Isael Maciel, Corinne Maufrais, Naomi Lyons, Nora Kawar, Chen Bibi, Caleb Eickmann, Alex Rosenberg, Deveney Dasilva, N De, Maurizio Del Poeta, Richard J. Bennett, Judith G. Berman, Iuliana V. Ene

This study identifies Mnl1 as a repressor of azole tolerance in Candida albicans by linking it to sphingolipid metabolism, mitochondrial activity, and PKA signaling.

bioRxiv · Sep 12, 2025 · PreprintMicrobiology

Genome-guided manipulation of regulators of morphogenesis in a C. albicans strain with low virulence is not sufficient to trigger a high-virulence phenotype

Ricardo Fróis-Martins, Sarah Mertens, Van Du T. Tran, Corinne Maufrais, Christophe d’Enfert, Dominique Sanglard, Salomé LeibundGut‐Landmann

This study shows that altering BRG1 and CYR1 in a low-virulence C. albicans strain does not increase its virulence in vivo, suggesting complex gene networks regulate fungal pathogenicity.

bioRxiv · Jul 16, 2025 · PreprintMicrobiology

Comprehensive mapping of the 5' and 3' untranslated regions of Aspergillus fumigatus reveals new insights into gene regulation

Lukas Schrettenbrunner, Corinne Maufrais, Guilhem Janbon, Edward W. J. Wallace, Matthew G. Blango

This study maps 5' and 3' untranslated regions of Aspergillus fumigatus using experimental methods, revealing new regulatory elements and alternative transcription start and stop sites.

bioRxiv · Jul 4, 2025 · PreprintMicrobiology

Polygenetic Determinants of Azole Resistance, Tolerance, and Heteroresistance in Candida albicans

Kyle Schutz, Cécile Gautier, Corinne Maufrais, Natacha Sertour, Marie‐Elisabeth Bougnoux, Christophe d’Enfert, Luke M. Evans, Stacey D. Smith, Iuliana V. Ene

This study identifies polygenic determinants of fluconazole susceptibility, tolerance, and heteroresistance in Candida albicans using GWAS on 557 isolates, revealing distinct genetic loci and mechanisms.

bioRxiv · Jun 29, 2025 · PreprintMicrobiology

Large circulation of a novel vesiculovirus in bats in the Mediterranean region

Dongsheng Luo, Markéta Harazim, Corinne Maufrais, Simon Bonas, Natália Martínková, Aude Lalis, Emmanuel Rivalyn Nakouné, Edgard Valery Adjogoua, Mory Douno, Blaise Kadjo, Marc López‐Roig, Jiří Pikula, Zheng‐Li Shi, Hervé Bourhy, Jordi Serra Cobo, Laurent Dacheux

The paper identifies a novel vesiculovirus, Mediterranean bat virus (MBV), circulating in bats across the Mediterranean region using a new RT-qPCR method and genomic analysis.

PLoS neglected tropical diseases · Jun 12, 2025Peer-reviewedMicrobiology

Step-wise evolution of azole resistance through copy number variation followed by KSR1 loss of heterozygosity in Candida albicans.

Pétra Vande Zande, Cécile Gautier, Nora Kawar, Corinne Maufrais, Katura Metzner, Elizabeth Wash, Annette K. Beach, Ryan Bracken, Eli Isael Maciel, Nívea Pereira de Sá, Caroline Mota Fernandes, Norma V. Solis, Maurizio Del Poeta, Scott G. Filler, Judith G. Berman, , Anna M. Selmecki

This study shows how azole resistance in Candida albicans evolves through copy number variation followed by KSR1 loss of heterozygosity, resulting in a >500-fold resistance increase.

PLoS Pathogens · Aug 30, 2024Peer-reviewedMicrobiology

Alternative TSS use is widespread in Cryptococcus fungi in response to environmental cues and regulated genome-wide by the transcription factor Tur1

Thi Tuong Vi Dang, Corinne Maufrais, Jessie Colin, Frédérique Moyrand, Isabelle Mouyna, Jean‐Yves Coppée, Chinaemerem U. Onyishi, Joanna Lipecka, Ida Chiara Guerrera, Robin C. May, Guilhem Janbon

The paper identifies widespread alternative TSS usage in Cryptococcus fungi in response to environmental cues and shows that the transcription factor Tur1 regulates this process genome-wide.

PLoS Biology · Jul 25, 2024Peer-reviewedMolecular Biology

POPULATION GENOMIC ANALYSIS OF CRYPTOCOCCUS BRAZILIAN ISOLATES REVEALS AN AFRICAN TYPE SUBCLADE DISTRIBUTION

Corinne Maufrais, Luciana Márcia de Oliveira, Rafael Wesley Bastos, Frédérique Moyrand, Flavia C. G. Reis, Clara Valero, Bianca Gimenez, Luísa J. Jozefowicz, Gustavo Henrique Goldman, Márcio Lourenço Rodrigues, Guilhem Janbon

This study analyzes the genomic structure of Brazilian Cryptococcus isolates, revealing an African-like subclade distribution and identifying a mutator phenotype in one isolate.

G3 Genes Genomes Genetics · Apr 2, 2021Peer-reviewedGenomics

Start codon context controls translation initiation in the fungal kingdom

Edward W. J. Wallace, Corinne Maufrais, Jade Sales-Lee, Laura Tuck, Luciana Márcia de Oliveira, Frank Feuerbach, Frédérique Moyrand, Prashanthi Natarajan, Hiten D. Madhani, Guilhem Janbon

The paper shows that start codon context regulates translation in fungi, affecting uORF usage and dual-protein localization.

Nucleic Acids Research · Jan 20, 2020Peer-reviewedGenomics

Generating genomic platforms to study Candida albicans pathogenesis

Mélanie Legrand, Sophie Bachellier‐Bassi, Keunsook K. Lee, Yogesh Chaudhari, Hélène Tournu, Laurence Arbogast, Hélène Boyer, Murielle Chauvel, Vitor Cabral, Corinne Maufrais, Audrey Nesseir, Irena Maslanka, Emmanuelle Permal, Tristan Rossignol, Louise A. Walker, , Christophe d’Enfert

The paper generates an ORFeome collection and associated tools for studying Candida albicans pathogenesis.

Nucleic Acids Research · Jun 25, 2018Peer-reviewedGenomics