Cécile Gautier

The paper develops and validates a 16-plex droplet digital PCR assay for accurate chromosome copy number quantification in C. albicans, showing strong correlation with whole-genome sequencing.

This study identifies Mnl1 as a repressor of azole tolerance in Candida albicans by linking it to sphingolipid metabolism, mitochondrial activity, and PKA signaling.

This study identifies polygenic determinants of fluconazole susceptibility, tolerance, and heteroresistance in Candida albicans using GWAS on 557 isolates, revealing distinct genetic loci and mechanisms.

This study shows how azole resistance in Candida albicans evolves through copy number variation followed by KSR1 loss of heterozygosity, resulting in a >500-fold resistance increase.