Passaging Human Tauopathy Patient Samples in Cells Generates Heterogeneous Fibrils with a Subpopulation Adopting Disease Folds
Zhikai Zeng, Karen Tsay, Vishnu Vijayan, Matthew P. Frost, Shikhar Prakash, Athena Quddus, Alexa Albert, Michael P. Vigers, Madhur Srivastava, Amanda L. Woerman, Songi Han
The paper shows that cell-passaged tau fibrils from CBD and PSP patients generate heterogeneous fibrils with a subpopulation resembling the original disease fold.
bioRxiv · Jul 19, 2023 · PreprintMolecular Biology