Author

Athena Quddus

University of California, San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:protein structure· 2 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Daniel R. SouthworthiD· 2 shared Eric TseiD· 2 shared Gregory E. MerziD· 2 shared Karen TsayiD· 2 shared Michael P. VigersiD· 2 shared Songi HaniD· 2 shared Alexa Albert· 1 shared Alissa L. NanaiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersNeuroscience

Daniel R. SouthworthORCID

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Author profile →

3 papers

Recent·Most cited

Distinct tau filament folds in familial frontotemporal dementia due to the MAPT S305I mutation

Henry S. Pan, Gregory E. Merz, Alissa L. Nana, Minh Quan Le, Hyunil Jo, Athena Quddus, Anthony Yung, Rian C. Kormos, Arthur A Melo, Eliana Marisa Ramos, Argentina Lario Lago, Salvatore Spina, Lea T. Grinberg, Howard J. Rosen, Eric Tse, , Daniel R. Southworth

This study identifies distinct tau filament structures in FTLD-tau caused by the MAPT S305I mutation, revealing a unique 4-layer architecture and potential RNA-like polyanion binding.

bioRxiv · Feb 15, 2026 · PreprintNeuroscience

Structure-specific Mini-Prion Model for Alzheimer's Disease Tau Fibrils

Vishnu Vijay, Gregory E. Merz, Karen Tsay, Andrew P. Longhini, Samuel Lobo, Athena Quddus, K. Nakagawa, Michael P. Vigers, Arthur A. Melo, Eric Tse, Shea Joan-Emma, M. Scott Shell, K S Kosik, Daniel R. Southworth, Songi Han

The paper designs synthetic tau fibrils that mimic AD and CTE structures, showing strong seeding ability and catalytic effects in vitro and in cells.

Alzheimer s & Dementia · Dec 1, 2025Peer-reviewedBiophysics

Passaging Human Tauopathy Patient Samples in Cells Generates Heterogeneous Fibrils with a Subpopulation Adopting Disease Folds

Zhikai Zeng, Karen Tsay, Vishnu Vijayan, Matthew P. Frost, Shikhar Prakash, Athena Quddus, Alexa Albert, Michael P. Vigers, Madhur Srivastava, Amanda L. Woerman, Songi Han

The paper shows that cell-passaged tau fibrils from CBD and PSP patients generate heterogeneous fibrils with a subpopulation resembling the original disease fold.

bioRxiv · Jul 19, 2023 · PreprintMolecular Biology