Preservation of Human Colonic Stem Cells Requires an ERK Dynamics Checkpoint Mediated by AKT
Lauren Riede, Alexander Borowiec, Saptarshi Mallick, Sohini Mallick, Jayati L. Chakrabarti, Curtis A. Thorne, Kelvin W. Pond
The paper shows that human colonic stem cells use an AKT-dependent ERK dynamics checkpoint to maintain tissue homeostasis by suppressing differentiation-inducing ERK pulses.
bioRxiv · Apr 11, 2026 · PreprintCell Biology