Kelvin W. Pond

This paper uses patient-derived colonic organoids to study how tumor microenvironment proteins affect nanoparticle uptake and delivery, showing improved targeting of chemoresistant cells.

The paper shows that human colonic stem cells use an AKT-dependent ERK dynamics checkpoint to maintain tissue homeostasis by suppressing differentiation-inducing ERK pulses.

The paper identifies pathogenic TMEM184B variants in six pediatric cases and shows they disrupt metabolic signaling and neural development through functional studies in zebrafish and human cells.