Curtis A. Thorne

This study shows myristate induces ER stress via ceramide synthases, and restoring sphingoid bases reduces intestinal ER stress.

The paper shows that human colonic stem cells use an AKT-dependent ERK dynamics checkpoint to maintain tissue homeostasis by suppressing differentiation-inducing ERK pulses.

This study uses high-throughput screens in human cells with authentic SARS-CoV-2 virus to identify neutralizing monoclonal antibodies and kinase inhibitors with minimal host toxicity.

This paper designs and evaluates Dyr726, a brain-penetrant multi-kinase inhibitor that targets PI3Kα, receptor tyrosine kinases, and WNT signaling, showing efficacy in preclinical cancer models.

The paper designs and optimizes a synthetic gene regulatory network using dCas12a, achieving higher reporter expression than dCas9-based systems.

The paper identifies and validates small molecule and natural product inhibitors targeting the VEGF-A/NRP-1 interaction, with potential applications in treating neuropathic pain, cancer, and SARS-CoV-2 infection.