Dual targeting of RET and SRC synergizes in RET fusion-positive cancer cells
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole Virginia Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix
This study shows that combining RET and SRC inhibitors enhances anti-cancer effects in RET fusion-positive cancers by suppressing PAK signaling and restoring sensitivity in resistant cells.
Molecular Oncology · Nov 5, 2025Peer-reviewedCancer Biology