Deep sequencing of proteotoxicity modifier genes uncovers a Presenilin-2/beta-amyloid-actin genetic risk module shared among alpha-synucleinopathies
Sumaiya Nazeen, Xinyuan Wang, Dina Zielinski, Isabel Lam, Erinc Hallacli, Ping Xu, Elizabeth Ethier, Ronya Strom, Camila A. Zanella, Vanitha Nithianandam, Dylan Ritter, Alexander Henderson, Nathalie G. Saurat, Jalwa Afroz, Andrew Nutter-Upham, , Vikram Khurana
The paper identifies a shared genetic risk module involving PSEN2 and actin regulation across alpha-synucleinopathies, linking them to Alzheimer's disease mechanisms.
bioRxiv · Mar 3, 2024 · PreprintGenomics