Author

Vanitha Nithianandam

Brigham and Women's HospitalORCID 0000-0002-0740-0758Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Organism:Drosophila· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

Mel Β. FeanyiD· 5 shared Xianjun DongiD· 3 shared Clemens R. ScherzeriD· 2 shared Hassan BukhariiD· 2 shared Matthew Joseph LeventhaliD· 2 shared Rachel A. BattagliaiD· 2 shared Souvarish SarkariD· 2 shared Alexander Henderson· 1 shared

Activity by Year

2023-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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5 shared papersNeuroscience

Mel Β. FeanyORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Single cell eQTL mapping reveals convergent glial-neuronal risk architecture in Parkinson's disease

Zechuan Lin, Jacob Parker, Vanitha Nithianandam, Sakthikumar Mathivanan, T Wang, Zhixiang Liao, Sean Simmons, Idil Tuncali, Xian Adiconis, Nathan Haywood, Beatrice Weykopf, Xufei Teng, Monika Sharma, Jie Yuan, Clare Baecher‐Allan, , Clemens R. Scherzer

The paper fine-maps PD GWAS signals across cell types, revealing convergent glial-neuronal risk genes and a shared vesiculopathy network.

bioRxiv · Apr 29, 2026 · PreprintGenetics

Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a Drosophila knock-in tauopathy model

Hassan Bukhari, Vanitha Nithianandam, Rachel A. Battaglia, Anthony Cicalo, Souvarish Sarkar, Aram Comjean, Yanhui Hu, Matthew Joseph Leventhal, Xianjun Dong, Mel Β. Feany

This study creates a Drosophila tauopathy model with the P251L mutation and uses single-cell RNA sequencing to identify molecular changes in neuronal and glial cells.

Genome Research · Apr 1, 2024Peer-reviewedNeuroscience

Deep sequencing of proteotoxicity modifier genes uncovers a Presenilin-2/beta-amyloid-actin genetic risk module shared among alpha-synucleinopathies

Sumaiya Nazeen, Xinyuan Wang, Dina Zielinski, Isabel Lam, Erinc Hallacli, Ping Xu, Elizabeth Ethier, Ronya Strom, Camila A. Zanella, Vanitha Nithianandam, Dylan Ritter, Alexander Henderson, Nathalie G. Saurat, Jalwa Afroz, Andrew Nutter-Upham, , Vikram Khurana

The paper identifies a shared genetic risk module involving PSEN2 and actin regulation across alpha-synucleinopathies, linking them to Alzheimer's disease mechanisms.

bioRxiv · Mar 3, 2024 · PreprintGenomics

Pathways controlling neurotoxicity and proteostasis in mitochondrial complex I deficiency

Vanitha Nithianandam, Souvarish Sarkar, Mel Β. Feany

The paper identifies pathways controlling neurodegeneration and proteostasis in mitochondrial complex I deficiency using a Drosophila model and genetic screens.

Human Molecular Genetics · Jan 26, 2024Peer-reviewedNeuroscience

Integrative analysis reveals a conserved role for the amyloid precursor protein in proteostasis during aging

Vanitha Nithianandam, Hassan Bukhari, Matthew Joseph Leventhal, Rachel A. Battaglia, Xianjun Dong, Ernest Fraenkel, Mel Β. Feany

The paper identifies a conserved role for APP in proteostasis during aging through genetic and multi-omics analyses in Drosophila and human models.

Nature Communications · Nov 3, 2023Peer-reviewedNeuroscience