The paper creates a DNA methylation aging atlas across 17 human tissues, identifying conserved and tissue-specific aging signatures and potential therapeutic targets.

bioRxiv · Jul 21, 2025 · PreprintBioinformatics

TNF-NFkB-p53 axis restricts in vivo survival of hPSC-derived dopamine neuron

Tae Wan Kim, So Yeon Koo, Markus Rießland, Fayzan F. Chaudhry, Benjamin Kolisnyk, Hyunwoo Cho, Marco Vincenzo Russo, Nathalie G. Saurat, Sanjoy Mehta, Ralph J. Garippa, Doron Betel, Lorenz Studer

The paper identifies p53-mediated apoptosis and TNF-NFkB signaling as key factors limiting survival of grafted dopamine neurons and shows that adalimumab treatment improves their engraftment and function in a PD mouse model.

Cell · Jun 11, 2024Peer-reviewedNeuroscience

Deep sequencing of proteotoxicity modifier genes uncovers a Presenilin-2/beta-amyloid-actin genetic risk module shared among alpha-synucleinopathies

Sumaiya Nazeen, Xinyuan Wang, Dina Zielinski, Isabel Lam, Erinc Hallacli, Ping Xu, Elizabeth Ethier, Ronya Strom, Camila A. Zanella, Vanitha Nithianandam, Dylan Ritter, Alexander Henderson, Nathalie G. Saurat, Jalwa Afroz, Andrew Nutter-Upham, , Vikram Khurana

The paper identifies a shared genetic risk module involving PSEN2 and actin regulation across alpha-synucleinopathies, linking them to Alzheimer's disease mechanisms.

bioRxiv · Mar 3, 2024 · PreprintGenomics