Dietary isoleucine content defines the metabolic and molecular response to a Western diet
Michaela E. Trautman, Cara L. Green, Michael Robert MacArthur, Krittisak Chaiyakul, Yasmine H. Alam, Chung‐Yang Yeh, Reji Babygirija, Isabella James, Michael Gilpin, Esther Zelenovskiy, Madelyn Green, Ryan N. Marshall, Alexander Raskin, Michelle M. Sonsalla, Victoria Flores, , Dudley W. Lamming
This study shows that reducing dietary isoleucine improves metabolic health in mice on a Western diet, with distinct molecular responses across sexes and strains.
Molecular Metabolism · Sep 10, 2025Peer-reviewedPhysiology