Maria K. Lehtinen

Simultaneous, real-time tracking of many neuromodulatory signals with Multiplexed Optical Recording of Sensors on a micro-Endoscope

This paper develops a micro-endoscope probe to simultaneously track multiple neuromodulators in real time using fluorescent sensors, demonstrating its use in brain slices and awake mice.

Temporal and cell-type specific SPAK-NKCC1 disruption following severe TBI in the developing gyrencephalic brain.

This study examines age-dependent changes in NKCC1 and SPAK expression following TBI in piglets, identifying potential therapeutic targets for pediatric TBI.

Multi-modal choroid plexus pathology in aging and Alzheimer's disease

This study creates a multi-modal atlas of choroid plexus pathology across aging and Alzheimer's disease, identifying fibrosis, calcification, and macrophage abnormalities as key features.

Fluid-Niche and Microglial Signatures Prime Robust Intraventricular Macrophage Response to Blood During Brain Development

This study identifies intraventricular macrophages (IVMs) as first responders to blood in developing brains, showing their dynamic behavior and unique transcriptional profiles.

Gestational LSD exposure in mouse rapidly reaches embryonic CSF and is associated with altered choroid plexus signaling, cerebral cortical development, and offspring behavior

This study shows maternal LSD exposure in mice rapidly reaches embryonic cerebrospinal fluid, activates choroid plexus, and leads to cortical and behavioral changes in offspring.

Natural language processing charts transcriptome evolution to design combination cancer therapies

This paper introduces RECODR, a computational pipeline that tracks transcriptome changes in cancer development and treatment to predict resistance mechanisms and design effective therapies.

Newly discovered base barrier cells provide compartmentalization of choroid plexus, brain and CSF

The paper identifies a novel fibroblast subtype in the choroid plexus that forms a barrier between the choroid plexus stroma, brain, and cerebrospinal fluid.

Optimized Mass Spectrometry Detection of Thyroid Hormones and Polar Metabolites in Rodent Cerebrospinal Fluid

The paper develops an optimized LC-MS method to measure thyroid hormones and metabolites in rodent CSF, revealing differences between pregnant and non-pregnant animals and across developmental stages.

A choroid plexus apocrine secretion mechanism shapes CSF proteome and embryonic brain development

The paper shows that apocrine secretion by the choroid plexus affects CSF proteome and brain development in mice, with maternal stressors disrupting this process.

Metabolomics of Mouse Embryonic CSF Following Maternal Immune Activation

This study uses metabolomics to analyze changes in mouse embryonic CSF after maternal immune activation, identifying elevated glucocorticoids and kynurenine pathway metabolites.

SCO-spondin knockout mice exhibit small brain ventricles and mild spine deformation

This study generates Sspo knockout mice and finds reduced brain ventricle size but only minor spine curvature defects.

A collaboration between immune cells and the choroid plexus epithelium in brain inflammation

The paper shows the ChP acts as an immune organ in brain inflammation, with immune cell interactions and epithelial cell specialization regulating the barrier.

LRP1 mediates leptin transport by coupling with the short-form leptin receptor in the choroid plexus

This study identifies LRP1 as a mediator of leptin transport across the blood-CSF barrier in the choroid plexus, coupled with the short-form leptin receptor, and shows its deletion leads to leptin resistance and obesity.

A cellular and spatial map of the choroid plexus across brain ventricles and ages

This study constructs a single-cell and spatial atlas of the choroid plexus in developing and adult mice, revealing cell types, regional gene expression, and cell-cell interactions.

MEIS-WNT5A axis regulates development of 4th ventricle choroid plexus

This study identifies the MEIS-WNT5A axis as critical for the development and morphology of the fourth ventricle choroid plexus.

Non-canonical, potassium-driven cerebrospinal fluid clearance

The paper identifies potassium-driven cerebrospinal fluid (CSF) clearance through the choroid plexus during a critical neurodevelopmental phase in mice, showing its role in preventing hydrocephalus.