Quantitative proteomic analysis reveals apoE4-dependent phosphorylation of the actin-regulating protein VASP
Zeynep Cakir, Samuel J. Lord, Yuan Zhou, Gwendolyn Μ. Jang, Benjamin J. Polacco, Manon Eckhardt, David Jimenez‐Morales, Billy W. Newton, Adam L. Orr, Jeffrey R. Johnson, Alexandre da Cruz, R. Dyche Mullins, Nevan J. Krogan, Robert W. Mahley, Danielle L. Swaney
The paper shows apoE4 increases VASP phosphorylation, disrupting actin interactions and affecting neurite outgrowth in Neuro-2a cells.
bioRxiv · Jun 6, 2022 · PreprintNeuroscience