Author

Yuan Zhou

Gladstone Institutes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

Click to filter author papers

Neuroscience· 4 Cell Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Organism:human· 2 Assay:imaging· 2

Frequent Co-Authors

Danielle L. SwaneyiD· 3 shared Nevan J. KroganiD· 3 shared Benjamin J. PolaccoiD· 2 shared Jeffrey R. JohnsoniD· 2 shared Lida DuiD· 2 shared Manon EckhardtiD· 2 shared Wenzhen DuaniD· 2 shared Aadhya Bavkar· 1 shared

Activity by Year

2022-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersSystems Biology

Danielle L. SwaneyORCID

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Computer vision-aided locomotor behavioral analysis identifies therapeutic motor signatures in a mouse model of Huntington disease

Lida Du, Zhenyu Wang, Qian Wu, Hongshuai Liu, Aadhya Bavkar, Yuan Zhou, Yukuan Shi, Lauren A Lim, Jiaxin Guo, Ziqi Qin, Christopher A. Ross, Wenzhen Duan

The paper introduces a computer vision framework to analyze fine motor behaviors in HD mice, identifying disease-specific motor signatures and a scoring system to assess therapeutic effects.

bioRxiv · Sep 7, 2026 · PreprintNeuroscience

Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication

Jyoti Batra, Magdalena Rutkowska, Yuan Zhou, Chengjin Ye, Rithika Adavikolanu, Janet M. Young, Durga Anand, Sooraj Verma, Haripriya Parthasarathy, Martin Gordon, Shivali Malpotra, Anastasija Čupić, Thomas Kehrer, Mélanie Dos Santos, Ronald Benjamin, , Nevan J. Krogan

Cell Host & Microbe · May 14, 2026Peer-reviewedSystems Biology

The COX2-PGE2-PKA Axis Suppresses Antiviral Immunity by Inhibiting mtDNA-Dependent STING Activation.

Pham Thuy Tien Vo, Julien Cicero, Zichen Wang, Hiroyuki Hakozaki, Thomas S. Hoang, Sendi Rafael Adame-Garcia, Dana J. Ramms, Kuniaki Sato, Erica J. Stevenson, Yuan Zhou, Katie Fan, Danielle L. Swaney, Nevan J. Krogan, Johannes Schöneberg, Uri Manor, Jorge Silvio Gutkind

This study identifies the COX2-PGE2-PKA axis as a negative regulator of mtDNA-STING signaling, which suppresses antiviral immunity by inhibiting STING activation through mitophagy.

bioRxiv · Apr 6, 2026 · PreprintCell Biology

Dynamic control of Raf-ERK signaling modulates neuronal activity across biological scales

Huaxun Fan, Eunjoo Kang, Yuan Zhou, Collin Michael Barnes, Nathan Gron, Hairuo Du, Catherine A. Christian, Xinzhu Yu, Kai Zhang

This study uses opto-miniRaf to show ERK signaling acutely modulates neuronal activity across multiple scales in cultured neurons and intact brains.

bioRxiv · Jan 8, 2026 · PreprintNeuroscience

Cell type-specific contributions to impaired blood-brain barrier and cerebral metabolism in presymptomatic 5XFAD mice

Minmin Yao, Na Sun, Raleigh M. Linville, Zhiliang Wei, Aaron Kakazu, Yuxiao Ouyang, Ruoxuan Li, Lida Du, Haitong Wang, Yuan Zhou, Yanli Jiang, Ziqin Zhang, Anna Li, Hanzhang Lu, Jiadi Xu, , Wenzhen Duan

The paper identifies cell type-specific transcriptomic changes in 5XFAD mice that link BBB dysfunction and metabolic dysregulation to early AD pathogenesis.

bioRxiv · Apr 23, 2025 · PreprintNeuroscience

Quantitative proteomic analysis reveals apoE4-dependent phosphorylation of the actin-regulating protein VASP

Zeynep Cakir, Samuel J. Lord, Yuan Zhou, Gwendolyn Μ. Jang, Benjamin J. Polacco, Manon Eckhardt, David Jimenez‐Morales, Billy W. Newton, Adam L. Orr, Jeffrey R. Johnson, Alexandre da Cruz, R. Dyche Mullins, Nevan J. Krogan, Robert W. Mahley, Danielle L. Swaney

The paper shows apoE4 increases VASP phosphorylation, disrupting actin interactions and affecting neurite outgrowth in Neuro-2a cells.

bioRxiv · Jun 6, 2022 · PreprintNeuroscience