Yeast de novo proteins integrate into cellular systems using ancient protein targeting and degradation pathways
Carly J. Houghton, Nelson Castilho Coelho, Annette Chiang, Aaron C. Wacholder, Stefanie Hedayati, Alison Guyer, Matayo Wankiiri-Hale, Hussain Raza, Nathan D. Lord, Saurin Bipin Parikh, Nejla Ozbaki‐Yagan, John Iannotta, Alexis Berger, Matthew L. Wohlever, Anne‐Ruxandra Carvunis, Allyson F. O’Donnell
This study investigates how de novo proteins in yeast integrate into cellular systems using ancient targeting and degradation pathways, revealing a conserved molecular signature that enables their ER localization and regulation.
bioRxiv · Aug 28, 2024 · PreprintEvolutionary Biology