Author

John Iannotta

University of PittsburghORCID 0009-0006-9969-9561Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Organism:yeast· 2 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Aaron C. WacholderiD· 2 shared Anne‐Ruxandra CarvunisiD· 2 shared Carly J. HoughtoniD· 2 shared Nelson Castilho CoelhoiD· 2 shared Saurin Bipin ParikhiD· 2 shared Alexis Berger· 1 shared Alison GuyeriD· 1 shared Allyson F. O’DonnelliD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersEvolutionary Biology

Aaron C. WacholderORCID

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2 papers

Recent·Most cited

Evolutionary BiologybioRxivPreprintSep 1, 2026

Environmental stress and phenotypic tradeoff modulate the adaptive potential of novel coding sequences for de novo gene birth

Lin Chou, Nelson Castilho Coelho, Saurin Bipin Parikh…·Anne‐Ruxandra Carvunis

The paper shows that environmental stress influences the phenotypic impact of de novo ORFs, with tradeoffs and stress-dependent growth effects observed in yeast.

DOI 10.64898/2026.08.24.746591

yeastproteomics

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Evolutionary BiologybioRxivPreprintAug 28, 2024

Yeast de novo proteins integrate into cellular systems using ancient protein targeting and degradation pathways

Carly J. Houghton, Nelson Castilho Coelho, Annette Chiang…·Allyson F. O’Donnell

This study investigates how de novo proteins in yeast integrate into cellular systems using ancient targeting and degradation pathways, revealing a conserved molecular signature that enables their ER localization and regulation.

7 citations

yeastproteomics

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