Author

Alexis R. Boscia

University of Virginia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 2 Bioengineering· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2

Frequent Co-Authors

Abhinav ArnejaiD· 2 shared Aditi S. Kodali· 2 shared Benjamin N. Hester· 2 shared Chance John LuckeyiD· 2 shared Conrad S. Niebuhr· 2 shared Elizabeth A. Stern-Green· 2 shared Emily D. Burnett· 2 shared James C. ZimringiD· 2 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

Abhinav ArnejaORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Red Blood Cell Transfusion is a Non-Canonical Immune Stimulus Characterized by the Suboptimal Induction of CD4+ T Cell Help

Jelena Medved, Abhinav Arneja, Neha Shah, Benjamin N. Hester, Emily D. Burnett, Alexis R. Boscia, Tamara C. Moscovich, Whitney Rose Swain, Aditi S. Kodali, Arwen Chandler, Gunnhildur A. Thorkelsdottir, Catherine J. W. Schwartzschild, Rachel J. Muppidi, Iman Cherkaoui, Jessica M. Strand, , Chance John Luckey

This study shows that RBC transfusion induces weak IgG class switching compared to vaccination, due to suboptimal T cell help, and activates T cells via a non-canonical pathway.

bioRxiv · Jun 26, 2025 · PreprintImmunology

Base Editing Rescue of Seizures and SUDEP in SCN8A Developmental Epileptic Encephalopathy

Caeley M Reever, Alexis R. Boscia, Tyler C J Deutsch, Mansi P. Patel, Raquel M. Miralles, Shrinidhi Kittur, Erik J. Fleischel, Atum M. Buo, Matthew S. Yorek, Miriam H. Meisler, Charles R. Farber, Manoj K. Patel

This study uses base editing to correct the SCN8A R1872W mutation in mice, reducing seizures and improving survival and comorbidities.

bioRxiv · Apr 9, 2025 · PreprintBioengineering

Transfusion of allogenic murine HOD red blood cells preferentially induces low-affinity, short-lived IgG antibodies that are germinal center independent

Jelena Medved, Abhinav Arneja, Tamara C. Moscovich, Neha Shah, Rachel J. Muppidi, Emily D. Burnett, Alexis R. Boscia, Benjamin N. Hester, Jayati Maram, Rishi Raghavan, Selby A Ireland, M Berberian, Elizabeth A. Stern-Green, Aditi S. Kodali, Conrad S. Niebuhr, , Chance John Luckey

bioRxiv · Jan 16, 2025 · PreprintImmunology

Parvalbumin Interneuron Impairment Leads to Synaptic Transmission Deficits and Seizures in SCN8A Epileptic Encephalopathy

Raquel M. Miralles, Alexis R. Boscia, Shrinidhi Kittur, Shreya R. Vundela, Eric R. Wengert, Manoj K. Patel

This study shows that impairments in parvalbumin interneurons due to SCN8A mutations cause synaptic transmission deficits and seizures in a mouse model of SCN8A epileptic encephalopathy.

bioRxiv · Feb 9, 2024 · PreprintNeuroscience