Matthew S. Yorek

Microenvironment T-Type calcium channels regulate neuronal and glial processes to promote glioblastoma growth

This study shows that microenvironment T-type calcium channels promote glioblastoma growth by regulating neuronal and glial processes, and that blocking these channels with mibefradil enhances the effectiveness of standard therapies.

FABP5 in Skin Macrophages Mediates Saturated Fat-Induced IL-1β Signaling in Obesity-Associated Psoriasis Development

This study shows that saturated fats drive psoriasis via FABP5-mediated IL-1β/IL-17 signaling in skin macrophages, exacerbating obesity-associated psoriasis.

Base Editing Rescue of Seizures and SUDEP in SCN8A Developmental Epileptic Encephalopathy

This study uses base editing to correct the SCN8A R1872W mutation in mice, reducing seizures and improving survival and comorbidities.

FABP4-mediated lipid accumulation and lipolysis in tumor associated macrophages promote breast cancer metastasis

This study shows that FABP4 in tumor-associated macrophages promotes breast cancer metastasis by mediating lipid accumulation and lipolysis in response to unsaturated fatty acids.