Extracellular Ca2+-Sensing Receptor (CaSR) Regulates Hypothalamic Function to Control Energy and Skeletal Metabolism in Mice
Jennifer J. Park-Sigal, Mariana Norton, Chia‐Ling Tu, Zhiqing Cheng, Nicole Fadahunsi, Hokyou Lee, Sunhee Kim, Alfred Li, Lea T. Grinberg, Gavin A. Bewick, Kevin G. Murphy, Wenhan Chang
This study shows that neuronal CaSR regulates energy and skeletal metabolism by modulating hypothalamic function in mice, affecting growth, bone mass, and metabolic parameters.
bioRxiv · May 22, 2025 · PreprintPhysiology