Author

Mariana Norton

Hammersmith HospitalORCID 0000-0002-9652-716XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Kevin G. MurphyiD· 4 shared Anna G. RobertsiD· 3 shared Brian LamiD· 3 shared Gavin A. BewickiD· 3 shared Giles S.H. YeoiD· 3 shared Phyllis PhuahiD· 3 shared Sijing ChengiD· 3 shared Aylin Carla HanyalogluiD· 2 shared

Activity by Year

2025-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersPhysiology

Kevin G. MurphyORCID

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4 papers

Recent·Most cited

The microbial tryptophan metabolite indole acts on the gastrointestinal tract to improve glucose homeostasis by enhancing GLP-1 secretion and L-cell differentiation

Phyllis Phuah, Mariana Norton, Sijing Cheng, Anna G. Roberts, Leah Meyer, Pei-En Chung, Cecilia Dunsterville, Rafal Karwowski, Brian Lam, Emile Otsubo, Sofia Aleksashina, Fiona Mary Gribble, Frank M. Reimann, Aylin Carla Hanyaloglu, Giles S.H. Yeo, , Kevin G. Murphy

This paper shows indole, a gut microbial metabolite, improves glucose control by boosting GLP-1 secretion and L-cell differentiation in mice, suggesting it could be used as a therapeutic for type 2 diabetes.

bioRxiv · Jun 24, 2025 · PreprintPhysiology

Extracellular Ca2+-Sensing Receptor (CaSR) Regulates Hypothalamic Function to Control Energy and Skeletal Metabolism in Mice

Jennifer J. Park-Sigal, Mariana Norton, Chia‐Ling Tu, Zhiqing Cheng, Nicole Fadahunsi, Hokyou Lee, Sunhee Kim, Alfred Li, Lea T. Grinberg, Gavin A. Bewick, Kevin G. Murphy, Wenhan Chang

This study shows that neuronal CaSR regulates energy and skeletal metabolism by modulating hypothalamic function in mice, affecting growth, bone mass, and metabolic parameters.

bioRxiv · May 22, 2025 · PreprintPhysiology

NodoMap: a spatio-cellular map of the mouse nodose ganglia

Sijing Cheng, Georgina K.C. Dowsett, Kara Rainbow, Mariana Norton, Anna G. Roberts, Phyllis Phuah, Gavin A. Bewick, Brian Lam, Giles S.H. Yeo, Kevin G. Murphy

The paper creates a spatio-cellular map of the mouse nodose ganglia using single nucleus RNA sequencing and spatial transcriptomics, revealing subtype-specific gene expression and spatial organization.

bioRxiv · May 11, 2025 · PreprintPhysiology

Enteropancreatic neurons drive the glucoregulatory response to ingested lipid

Anna G. Roberts, Leah Meyer, Jieruo Liu, Mariana Norton, Phyllis Phuah, Aldara Martin Alonso, Georgina K.C. Dowsett, Sijing Cheng, Cecilia Dunsterville, Pei-En Chung, Yuxuan Tao, Tobias Smitherman-Cairns, Alexandra B. Deutsch, Abhisekh Chatterjee, Brian Lam, , Kevin G. Murphy

This study shows that enteropancreatic neurons expressing NTSR1 mediate olive oil's effect on glucose tolerance by stimulating insulin release.

bioRxiv · May 9, 2025 · PreprintPhysiology