Kevin G. Murphy

This paper shows indole, a gut microbial metabolite, improves glucose control by boosting GLP-1 secretion and L-cell differentiation in mice, suggesting it could be used as a therapeutic for type 2 diabetes.

This study shows that neuronal CaSR regulates energy and skeletal metabolism by modulating hypothalamic function in mice, affecting growth, bone mass, and metabolic parameters.

The paper creates a spatio-cellular map of the mouse nodose ganglia using single nucleus RNA sequencing and spatial transcriptomics, revealing subtype-specific gene expression and spatial organization.

This study shows that enteropancreatic neurons expressing NTSR1 mediate olive oil's effect on glucose tolerance by stimulating insulin release.

The paper identifies and catalogs druggable targets in human colonic enteroendocrine cells using bulk and single-cell RNA sequencing, and functionally validates two novel receptors.