Author

Ali Ahmed Diaz

Howard Hughes Medical Institute and Division of Biology and Biological Engineering, California Institute of Technology; Pasadena, CA, 91125, USA

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Synthetic Biology· 1

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:protein structure· 1

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Albert Qiang· 1 shared Andrew C. LuiD· 1 shared Bo GuiD· 1 shared Daniel J. SiegwartiD· 1 shared Evan Zhang· 1 shared Haley Larson· 1 shared Hao ZhuiD· 1 shared James M. LintoniD· 1 shared

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1 shared paperSynthetic Biology

Albert Qiang

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1 paper

Recent·Most cited

Synthetic BiologybioRxivPreprintApr 16, 2025

Engineered protein circuits for cancer therapy

Andrew C. Lu, Lukas Moeller, Stephen Moore…·Michael B. Elowitz

This paper engineers protease-based protein circuits that selectively kill RAS-mutant cancer cells and suppress tumors, showing resistance reduction and cytotoxicity independent of oncogene addiction.

DOI 10.1101/2025.04.16.647665

humanprotein structure

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