Daniel J. Siegwart

This study identifies CLSTN3B as a driver of MASLD by promoting LD biogenesis and altering lipid partitioning between LDs and mitochondria, leading to mitochondrial dysfunction and oxidative stress.

This study shows that liver cancer initiation depends on metabolic zonation but is not linked to premalignant clonal expansion.

SORT LNPs enable efficient Cas9-mediated repair of a pathogenic allele in skeletal muscle in a mouse model of LGMDR7.

This paper engineers protease-based protein circuits that selectively kill RAS-mutant cancer cells and suppress tumors, showing resistance reduction and cytotoxicity independent of oncogene addiction.