Author

Lukas Moeller

California Institute of TechnologyORCID 0000-0002-4375-8837Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:protein structure· 1

Frequent Co-Authors

Andrew C. LuiD· 2 shared Evan Zhang· 2 shared Kevin Ho· 2 shared Michael B. ElowitziD· 2 shared Albert Qiang· 1 shared Ali Ahmed Diaz· 1 shared Bo GuiD· 1 shared Daniel J. SiegwartiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersSynthetic Biology

Andrew C. LuORCID

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2 papers

Recent·Most cited

Engineered caspases directly rewire mutant Ras to cell death

Lukas Moeller, Andrew C. Lu, Kevin Ho, Evan Zhang, Michael B. Elowitz

This paper engineers caspases to selectively kill cells with mutant Ras by reconstituting active complexes upon detection, showing potent in vitro efficacy against cancer lines.

bioRxiv · Sep 3, 2026 · PreprintSynthetic Biology

Engineered protein circuits for cancer therapy

Andrew C. Lu, Lukas Moeller, Stephen Moore, Kevin Ho, Victoria Tobin, Albert Qiang, Evan Zhang, Zhijie Li, Mengmeng Wang, Shiyu Xia, Mark W. Budde, Haley Larson, Ali Ahmed Diaz, Bo Gu, James M. Linton, , Michael B. Elowitz

This paper engineers protease-based protein circuits that selectively kill RAS-mutant cancer cells and suppress tumors, showing resistance reduction and cytotoxicity independent of oncogene addiction.

bioRxiv · Apr 16, 2025 · PreprintSynthetic Biology