Engineered protein circuits for cancer therapy
Andrew C. Lu, Lukas Moeller, Stephen Moore, Kevin Ho, Victoria Tobin, Albert Qiang, Evan Zhang, Zhijie Li, Mengmeng Wang, Shiyu Xia, Mark W. Budde, Haley Larson, Ali Ahmed Diaz, Bo Gu, James M. Linton, , Michael B. Elowitz
This paper engineers protease-based protein circuits that selectively kill RAS-mutant cancer cells and suppress tumors, showing resistance reduction and cytotoxicity independent of oncogene addiction.
bioRxiv · Apr 16, 2025 · PreprintSynthetic Biology