Divergent response to radio-immunotherapy is defined by intrinsic features of the tumor microenvironment
Jacob Gadwa, Justin Yu, Miles Piper, Michael W. Knitz, Laurel B. Darragh, Nicholas A. Olimpo, Sophia Corbo, Jessica I. Beynor, Brooke Neupert, Alexander T. Nguyen, Chloe A. Hodgson, Diemmy Nguyen, Khalid N.M. Abdelazeem, Anthony J. Saviola, Laurène Pousse, , Sana D. Karam
This study shows that combining immunotherapies can lead to divergent tumor responses based on the tumor microenvironment, with Treg depletion reversing progression in pancreatic cancer.
Journal for ImmunoTherapy of Cancer · Jan 1, 2025Peer-reviewedImmunology