Christian Klein

This study shows that IL15/IL15Rα complex with radiation therapy requires Treg depletion to induce anti-tumor immunity and that PD1-IL2v enhances CD8 T cell activation and function.

The paper examines B cell dynamics in different meningeal compartments of a progressive MS mouse model, identifying anti-CD20 resistant dural B cells that persist in the brain during remission.

This study shows that chronic antigen exposure leads to T cell exhaustion, reducing the effectiveness of T cell bispecific therapies in solid tumors.

This study shows that combining immunotherapies can lead to divergent tumor responses based on the tumor microenvironment, with Treg depletion reversing progression in pancreatic cancer.