Author

Lifeng Pan

Shanghai Institute of Organic ChemistryORCID 0000-0002-9229-6288Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Organism:mouse· 1

Frequent Co-Authors

Alice Biosa· 1 shared Elisa GreggioiD· 1 shared Francesca PischeddaiD· 1 shared Giovanni PiccoliiD· 1 shared Jianping Liu· 1 shared Luisa PonzoniiD· 1 shared María Dolores Pérez‐CarrióniD· 1 shared Maria‐Daniela CirnaruiD· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperNeuroscience

Alice Biosa

Mutual co-authors in cluster

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2 papers

Recent·Most cited

LRRK2 G2019S kinase activity triggers neurotoxic NSF aggregation

Francesca Pischedda, Maria‐Daniela Cirnaru, Luisa Ponzoni, Michele Sandre, Alice Biosa, María Dolores Pérez‐Carrión, Oriano Marin, Michele Morari, Lifeng Pan, Elisa Greggio, Rina Bandopadhyay, Mariaelvina Sala, Giovanni Piccoli

This study shows that LRRK2 G2019S kinase activity promotes NSF aggregation, which is toxic to neurons, and that autophagy can clear these aggregates and improve motor and cognitive function in a mouse model.

Brain · Feb 26, 2021Peer-reviewedNeuroscience

Mechanistic insight into the interactions of NAP1 with NDP52 and TAX1BP1 for the recruitment of TBK1

Tao Fu, Jianping Liu, Yingli Wang, Xingqiao Xie, Shichen Hu, Lifeng Pan

The paper reports atomic structures of NDP52 and TAX1BP1 SKICH domains complexed with NAP1, revealing interaction mechanisms and TBK1-mediated phosphorylation effects on TAX1BP1.

bioRxiv · Feb 12, 2018 · PreprintBiophysics