Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease
Subhash Kulkarni, Monalee Saha, Jared Slosberg, Alpana Singh, Sushma Nagaraj, Laren S. Becker, Chengxiu Zhang, Alicia Bukowski, Zhuolun Wang, Guosheng Liu, Jenna M. Leser, Mithra R. Kumar, Shriya Bakhshi, Matthew J Anderson, Mark B. Lewandoski, , Pankaj Jay Pasricha
This study shows that age-related changes in the lineage composition of the enteric nervous system affect gut health, with mesoderm-derived neurons becoming dominant and functional effects on intestinal motility that can be reversed by GDNF.
eLife · Aug 8, 2023Peer-reviewedNeuroscience