Author

Pankaj Jay Pasricha

Mayo ClinicORCID 0000-0002-8727-683XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Subhash KulkarniiD· 4 shared Monalee SahaiD· 3 shared Sushma NagarajiD· 2 shared Adrienne C. DeBrosse· 1 shared Alicia Bukowski· 1 shared Alpana SinghiD· 1 shared Amanda M. ClarkiD· 1 shared Andrey MorguniD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersNeuroscience

Subhash KulkarniORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Development of a Novel Benzodiazepine to Delineate Peripheral GABA-A Signaling Mechanisms in Visceral Pain Syndromes

Michael S. Poslusney, Qian Li, Ingrid P. Buchler, Yifang Huang, Liansheng Liu, Yaohui Zhu, Subhash Kulkarni, Gregory V. Carr, Adrienne C. DeBrosse, Noelle White, Diane E. Peters, James C. Barrow, Pankaj Jay Pasricha

This study develops a novel benzodiazepine, Li633, that targets peripheral GABAA receptors to reduce visceral pain in IBS and FD models.

Cellular and Molecular Gastroenterology and Hepatology · Jan 1, 2026Peer-reviewedNeuroscience

Monocytes Mobilized by Gut Neurons Remodel the Enteric Nervous System

Sravya Kurapati, Changsik Shin, Krisztina Szabo, Yu Liu, Azree Zaffran Ashraf, Balázs Koscsó, Chinmayee Priyadarsini Dash, Katherine L. Kruckow, L Guerrero Navarro, Amanda M. Clark, Monalee Saha, Sushma Nagaraj, Wenhui Wang, Jun Zhu, Kevin Brown, , Milena Bogunovic

The paper identifies that post-inflammatory GI dysmotility results from ENS remodeling driven by monocyte recruitment and neuroinflammation, which can be prevented by enhancing HIF1 signaling in enteric neurons.

The Journal of Experimental Medicine · Dec 20, 2025Peer-reviewedImmunology

Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease

Subhash Kulkarni, Monalee Saha, Jared Slosberg, Alpana Singh, Sushma Nagaraj, Laren S. Becker, Chengxiu Zhang, Alicia Bukowski, Zhuolun Wang, Guosheng Liu, Jenna M. Leser, Mithra R. Kumar, Shriya Bakhshi, Matthew J Anderson, Mark B. Lewandoski, , Pankaj Jay Pasricha

This study shows that age-related changes in the lineage composition of the enteric nervous system affect gut health, with mesoderm-derived neurons becoming dominant and functional effects on intestinal motility that can be reversed by GDNF.

eLife · Aug 8, 2023Peer-reviewedNeuroscience

Intestinal Bacteria Maintain Adult Enteric Nervous System and Nitrinergic Neurons via Toll-like Receptor 2-induced Neurogenesis in Mice

Shadi Yarandi, Subhash Kulkarni, Monalee Saha, Kristyn E. Sylvia, Cynthia L. Sears, Pankaj Jay Pasricha

This study shows that intestinal bacteria maintain adult enteric neurons via TLR2-induced neurogenesis in mice, with implications for treating colonic motility disorders.

Gastroenterology · Mar 29, 2020Peer-reviewedNeuroscience