Intrinsically disordered insert from SH2D2A rewires CD19 CAR signaling via Tyr290
Pawel P. Borowicz, Brian C. Gilmour, Hanna Chan, Ramakrishna Prabhu Gopalakrishnan, Timo Peters, René Platzer, Jacqueline Seigner, Johan Georg Visser, Hanna Kjelstrup, Aliki Popidou, Manal el Darwich, Ivan Abbedissen, Sebastian L. Andree, Stian Foss, Gustavo Antonio de Souza, , Spurkland Anne
This study identifies a specific tyrosine residue in an intrinsically disordered SH2D2A sequence that rewires CD19 CAR signaling and surface expression.
bioRxiv · Feb 5, 2026 · PreprintImmunology