Synthetic peptide hydrogels as a model of the bone marrow niche demonstrate efficacy of a combined CRISPR-CAR T-cell therapy for acute myeloid leukaemia
W. Sebastian Doherty-Boyd, Penelope M. Tsimbouri, Vineetha Jayawarna, Matthew Walker, Aqeel F. Taqi, Niall Mahon, R.M. Dominic Meek, Peter S. Young, Aline F. Miller, Adam G. West, Manuel Salmerón‐Sánchez, Matthew John Dalby, Hannah Donnelly
The paper develops a synthetic BM niche model to test CRISPR-CAR T-cell therapy for AML, showing its efficacy in a human-like environment.
Biomaterials · Oct 26, 2025Peer-reviewedBioengineering