Functional evaluation of a natural AAV capsid liver targeting motif in human hepatocytes
Carmen Unzu, Amanda X. Chen, Liliana Mâncio-Silva, Eric M. Zinn, Yanhe Wen, Carla Llinares, Andrea Llanos, Cindy Zhu, Allegra Fieldsend, Julio C. Sanmiguel, Beatrice Bissig-Choisat, Karl‐Dimiter Bissig, Ian E. Alexander, Sangeeta N. Bhatia, Luk H. Vandenberghe
The paper evaluates a natural AAV capsid liver targeting motif in human hepatocytes using in vivo and in vitro models, showing its role in liver targeting and the impact of PEG on transduction.
bioRxiv · Aug 20, 2026 · PreprintMolecular Biology