Author

Karl‐Dimiter Bissig

Duke Medical CenterORCID 0000-0002-9577-9250Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:CRISPR screen· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Adam B. Castoreno· 1 shared Alexandria M. DoerfleriD· 1 shared Allegra Fieldsend· 1 shared Amanda X. CheniD· 1 shared Andrea Llanos· 1 shared Ayrea E. HurleyiD· 1 shared Beatrice Bissig-ChoisatiD· 1 shared Carla LlinaresiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenetics

Adam B. Castoreno

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Functional evaluation of a natural AAV capsid liver targeting motif in human hepatocytes

Carmen Unzu, Amanda X. Chen, Liliana Mâncio-Silva, Eric M. Zinn, Yanhe Wen, Carla Llinares, Andrea Llanos, Cindy Zhu, Allegra Fieldsend, Julio C. Sanmiguel, Beatrice Bissig-Choisat, Karl‐Dimiter Bissig, Ian E. Alexander, Sangeeta N. Bhatia, Luk H. Vandenberghe

The paper evaluates a natural AAV capsid liver targeting motif in human hepatocytes using in vivo and in vitro models, showing its role in liver targeting and the impact of PEG on transduction.

bioRxiv · Aug 20, 2026 · PreprintMolecular Biology

In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene

Marco De Giorgi, So Hyun Park, Adam B. Castoreno, Mingming Cao, Ayrea E. Hurley, Lavanya Saxena, Marcel A. Chuecos, Christopher J. Walkey, Alexandria M. Doerfler, Mia N. Furgurson, M. Cecilia Ljungberg, Kalyani R. Patel, Sarah Hyde, Tyler Chickering, Stephanie Lefebvre, , William R. Lagor

This paper introduces a method to increase the proportion of correctly repaired hepatocytes in the liver through transient gene inhibition and transgene delivery, achieving a 25% increase in targeted cells and five-fold transgene expression.

Science Translational Medicine · Feb 12, 2025Peer-reviewedGenetics