DRG meningeal tertiary lymphoid structures are regulated by B cells as a pronociceptive locus after peripheral nerve injury
Tusar Kanta Acharya, Vipul K. Pandey, Kendal F. Willcox, Nathan T. Fiore, Gabriel V. Lucena-Silva, Jayden A. O'Brien, Allison M. Barry, Joseph B. Lesnak, Sever M Zagrai, David M. Ruiz, Younus A. Zuberi, Michael J. Lacagnina, Pooja Singhmar, Lisa Janssen, Abbie V. Viscardi, , Peter M. Grace
The paper shows that B cell-derived IgG in DRG meninges forms tertiary lymphoid structures (TLSs) that drive neuropathic pain after peripheral nerve injury, and disrupting TLSs prevents pain.
bioRxiv · Aug 18, 2026 · PreprintNeuroscience