Jayden A. O'Brien

The paper examines molecular and physiological changes in dorsal root ganglia from individuals with and without opioid use disorder, identifying altered neuroimmune signatures and sensitized sensory neurons.

The paper shows that B cell-derived IgG in DRG meninges forms tertiary lymphoid structures (TLSs) that drive neuropathic pain after peripheral nerve injury, and disrupting TLSs prevents pain.

The paper identifies microglia-like cells in human dorsal root ganglia and shows their changes in diabetic neuropathy.

The paper investigates T-cell distribution in the dorsal root ganglion across species, sex, and age, finding similar levels in humans, non-human primates, and pigs, but fewer in rats and absent in mice, with sex and age differences in humans.

The paper investigates neurodegeneration in dorsal root ganglia across diabetes and diabetic painful neuropathy stages, identifying early molecular changes and highlighting the need for early intervention.

This study identifies transcriptomic signatures in GBS patients that reveal leukocyte interactions with peripheral nerves and pain pathways, suggesting therapeutic targets for neuropathic pain.

The paper integrates human DRG proteomics with multi-omic data to identify TNFα signalling as a sexually dimorphic pathway in the PNS.