Cancers modulate p53 truncal neoantigen display to evade T cell detection
Koji Haratani, Bruce B. Reinhold, Jonathan S. Duke‐Cohan, Caroline G. Fahey, Kemin Tan, Robert J. Mallis, Alexander Gusev, Kenneth L. Kehl, Jia Luo, Elizabeth L. Holliday, Daniel J. Masi, Allyson Karmazyn, Katarzyna J. Zienkiewicz, Connor J. Hennessey, Rafael B. Blasco, , Ellis L. Reinherz
This study identifies that cancers limit p53 neoantigen display on MHC molecules, evading T cell detection through immune selection and ERAP1-mediated destruction.
bioRxiv · Nov 26, 2025 · PreprintImmunology