David Allen Barbie

This paper identifies MA2, a small-molecule agonist of MDA5 that enhances antiviral and antitumor immunity by dynamically stabilizing MDA5 filaments.

This paper develops LIME, a bacterial platform that engagers T and NK cells to target tumors, showing enhanced cytotoxicity and immune response in preclinical models.

This study investigates vascular impairment in Rett syndrome by analyzing patient-derived endothelial cells and identifies miR126-3p as a mediator of vascular dysfunction.

The paper develops a microphysiological model of lung fibrosis to study myofibroblast-vascular interactions, finding that myofibroblasts reduce angiogenesis and vasculogenesis through TGF-β1 and reduced VEGF.

This study identifies common survival mechanisms between drug-tolerant persisters and immunotherapy persisters, showing they share reduced mitochondrial apoptotic sensitivity and cross-resistance to therapies.

This study identifies that cancers limit p53 neoantigen display on MHC molecules, evading T cell detection through immune selection and ERAP1-mediated destruction.