A dynamic molecular glue targets a plastic MDA5 filament interface to stimulate innate immunity
This paper identifies MA2, a small-molecule agonist of MDA5 that enhances antiviral and antitumor immunity by dynamically stabilizing MDA5 filaments.
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Dana-Farber Cancer InstituteORCID 0000-0002-1767-6854Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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This paper identifies MA2, a small-molecule agonist of MDA5 that enhances antiviral and antitumor immunity by dynamically stabilizing MDA5 filaments.
Tatsuya Osaki, Zhengpeng Wan, Koji Haratani…·Mriganka Sur
This study investigates vascular impairment in Rett syndrome by analyzing patient-derived endothelial cells and identifies miR126-3p as a mediator of vascular dysfunction.
Koji Haratani, Bruce B. Reinhold, Jonathan S. Duke‐Cohan…·Ellis L. Reinherz
This study identifies that cancers limit p53 neoantigen display on MHC molecules, evading T cell detection through immune selection and ERAP1-mediated destruction.