Author

Jonathan S. Duke‐Cohan

Dana-Farber Cancer InstituteORCID 0000-0002-9478-9609Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Ellis L. ReinherziD· 2 shared Kemin TaniD· 2 shared Matthew J. LangiD· 2 shared Patrick Hall LizotteiD· 2 shared Robert J. MallisiD· 2 shared Alexander GuseviD· 1 shared Allyson Karmazyn· 1 shared Amelia Seabury· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersImmunology

Ellis L. ReinherzORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Atomistic TCR-ligand interactions shape memory T-cell differentiation

Aoi Akitsu, Kemin Tan, Robert J. Mallis, Matthew Aaron Booker, Jonathan S. Duke‐Cohan, Kristine N. Brazin, Evan H. Kirkpatrick, Andrew Parkins, Amelia Seabury, Sarita Aryal, Vincenzo Cinella, Jonathan J. Lee, Kaveri I. Uberoy, Jenna K. Koenig, Matthew Biddle, , Ellis L. Reinherz

The paper identifies how TCR-ligand interactions influence memory T-cell differentiation by analyzing clonotype-specific signaling and functional outcomes.

The Journal of Immunology · Jul 28, 2026Peer-reviewedImmunology

Cancers modulate p53 truncal neoantigen display to evade T cell detection

Koji Haratani, Bruce B. Reinhold, Jonathan S. Duke‐Cohan, Caroline G. Fahey, Kemin Tan, Robert J. Mallis, Alexander Gusev, Kenneth L. Kehl, Jia Luo, Elizabeth L. Holliday, Daniel J. Masi, Allyson Karmazyn, Katarzyna J. Zienkiewicz, Connor J. Hennessey, Rafael B. Blasco, , Ellis L. Reinherz

This study identifies that cancers limit p53 neoantigen display on MHC molecules, evading T cell detection through immune selection and ERAP1-mediated destruction.

bioRxiv · Nov 26, 2025 · PreprintImmunology

The fitness consequences of genetic variation in wild populations of mice

Rowan D.H. Barrett, Stefan Laurent, Ricardo Mallarino, Susanne P. Pfeifer, Charles C.Y. Xu, Matthieu Foll, Kazumasa Wakamatsu, Jonathan S. Duke-Cohan, Jeffrey D. Jensen, Hopi E. Hoekstra

The paper investigates how genetic variation in wild mice affects fitness by linking genotype to phenotype and allele frequency changes through field and lab experiments.

bioRxiv · Aug 21, 2018 · PreprintEvolutionary Biology