E-cadherin-mediated neighborhood surveillance dictates pre-malignant outcomes
Elizabeth A.N. Thompson, Clara Schimmer, Tatiana Omelchenko, Michele Paganini, Jesse S. S. Novak, Sienna T. Muller, Alain R. Bonny, Marina Schernthanner, Sairaj M. Sajjath, Charlotte J. Bell, Alp Gorgulu, S. Martina Parigi, Katherine S. Stewart, Priyam Banerjee, Elaine V. Fuchs, Stephanie J. Ellis
The paper shows E-cadherin redistribution creates tension heterogeneity, triggering cell competition that eliminates pre-malignant cells, but this system can fail, leading to tumor susceptibility.
bioRxiv · Sep 4, 2026 · PreprintCell Biology