A cocktail of SARS-CoV-2 spike stem helix domain and receptor binding domain human monoclonal antibodies prevent the emerge of viral escape mutants
Yao Ma, Chengjin Ye, Michael S. Piepenbrink, Sara Hussein Mahmoud, Anastasija Čupić, Esmeralda Gracián-Castro, Nathaniel D. Jackson, Mahmoud Bayoumi, Alvaro Souto Padron, Adolfo García‐Sastre, Gregory C. Ippolito, Mark R. Walter, James J. Kobie, Luis Martínez‐Sobrido
This study shows that a combination of antibodies targeting both the SARS-CoV-2 spike protein's receptor binding domain (RBD) and stem helix (SH) domains prevents the emergence of viral escape mutants.
bioRxiv · Oct 16, 2025 · PreprintMicrobiology